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{[5-(5-nitro-2-furyl)-1,3,4-oxadiazol-2-yl]thio}acetic acid
- Development stage
- Preclinical
- Modality
- Small Molecules
01
Overview
This compound is a synthetic small molecule belonging to the nitrofuran class. It features a furan ring with a nitro group and an oxadiazole moiety linked via a thioacetic acid side chain. The primary known mechanism of action is inhibition of the enzyme aldose reductase (AKR1B1), which plays a role in the polyol pathway and is implicated in diabetic complications. The compound has been studied experimentally but does not have established clinical use or approval as a pharmaceutical agent. Its main research interest lies in its potential as an aldose reductase inhibitor for conditions such as diabetic complications and possibly other metabolic or inflammatory diseases[2][4][7].
- Other names
- 2-{[5-(5-nitro-2-furyl)-1,3,4-oxadiazol-2-yl]thio}acetic acid{[5-(5-nitrofuran-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetic acidAcide {[5-(5-nitro-2-furyl)-1,3,4 oxadiazol 2 yl]sulfanyl}acétique{[5-(5-NITRO–FURYL)–1_3_4-OXADIAZOL–YL]THIO}ACETIC ACID
02
Targets
AR (Adrenergic receptors)
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